Chemoselectivity of cobalt-catalysed carbonylation—A reliable platform for the synthesis of fluorinated benzoic acids

详细信息    查看全文

• 作者：Vadim P. Boyarskiy ; Marina S. Fonari ; Tatiana S. Khaybulova ; Maria Gdaniec ; Yurii A. Simonov
• 关键词：Carbonylation ; Aryl halides ; Cobalt carbonyl ; Fluorinated benzoic acids ; Crystal structure
• 刊名：Journal of Fluorine Chemistry
• 出版年：2010
• 出版时间：January 2010
• 年：2010
• 卷：131
• 期：1
• 页码：81-85
• 全文大小：247 K

文摘

The cobalt-catalysed methoxycarbonylation of polysubstituted bromo,fluoro- and chloro,fluorobenzenes and 1,2,4-trichlorobenzene with emphasis on the chemo- and regio-selectivity of the reaction is described. The structures of isolated products of 1,4-dichloro-2-fluorobenzene carbonylation were determined by single-crystal X-ray diffraction. The fact that the fluorine substituents in the studied compounds remain intact indicates in favor of the anion-radical activation of aryl halides by a cobalt catalyst. For the first time, a universal method of preparation of the various fluorobenzoic acid derivatives from available raw materials with a good yield has been elaborated.