• 作者：Christian Esteban Lezó ; n ; Patricia Mabel Pintos ; Marí ; a Itatí ; Olivera ; Clarisa Bozzini ; Patricia Mó ; nica Boyer ; ^{pboyer59@hotmail.com}
• 关键词：Retraso del crecimiento ; Propranolol ; Calidad ó ; sea ; Competencia biomecá ; nica
• 刊名：Endocrinolog¨ªa y Nutrici¨®n
• 出版年：2012
• 出版时间：January, 2012
• 年：2012
• 卷：59
• 期：1
• 页码：9-20
• 全文大小：499 K

Objective

To assess in a growth retardation (GR) model the impact of different propranolol (P) doses on anthropomorphometric and biomechanical variables of the appendicular skeleton.

Materials and methods

Twenty-one day-old male Wistar rats were divided into the following groups: control (C), C + P3.5 (CP3.5); C + P7 (CP7); C + P10.5 (CP10.5); C + P14 (CP14); ED, ED + P3.5 (EDP3.5); ED + P7 (EDP7); ED + P10.5 (EDP10.5), and ED + P14 (EDP14). Control animals with/without P were fed a rodent diet ad libitum. GR rats with/without P were given 80 % of the same diet per 100 g body weight for 4 weeks (T4). Propranolol 3.5, 7, 10.5, and 14 mg/kg/day was intraperitoneally injected 5 days/week for 4 weeks to the CP3.5 and EDP3.5; CP7 and EDP7; CP10.5 and EDP10.5, and CP14 and EDP14 groups respectively.

Results

At T4, energy restriction had negative effects upon overall growth, femur, and its mechanical competence. Propranolol improved bone rigidity in GR animals at doses of 7 and 10.5 mg/kg/day, with a maximum response at 7 mg/kg/day.

Conclusions

Propranolol 7 mg/kg/day would be the most effective dose for modeling incorporation of bone, as shown by the increased skeletal structural and mechanic efficiency in this animal model of growth retardation. Such effect may result from maintenance of mechanosensor viability, changes in its sensitivity, the biomechanical reference point and/or effector response in GR rats.