BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation

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• 作者：Mayu Isono¹ ; ² ; Atsuko Niimi³ ; Takahiro Oike⁴ ; Yoshihiko Hagiwara¹ ; ⁴ ; Hiro Sato⁴ ; Ryota Sekine¹ ; Yukari Yoshida² ; Shin-Ya Isobe⁵ ; Chikashi Obuse⁵ ; Ryotaro Nishi⁶ ; Elena Petricci⁷ ; Shinichiro Nakada⁸ ; Takashi Nakano² ; ³ ; ⁴ ; Atsushi Shibata¹ ; ⁹ ; ^{shibata.at@gunma-u.ac.jp}
• 关键词：ATM ; DNA-end resection ; BRCA1 ; 53BP1 ; RIF1 ; PP4C ; NHEJ ; HR
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：520-532
• 全文大小：3097 K
• 卷排序：18

文摘

53BP1 is phosphorylated by ATM in S/G2, followed by transient RIF1 recruitment Inhibiting resection sustains p53BP1-RIF1 interaction BRCA1 promotes 53BP1 dephosphorylation and RIF1 release PP4C participates in 53BP1 dephosphorylation, promoting RIF1 release and resection