Xenoestrogens OP, BPA, NP, MBP showed high affinity for SHBG on docking simulation.
High overlap of SHBG residues among dihydrotestosterone and the four xenoestrogens.
Common H-bond with residue Asn-82 for dihydrotestosterone and four xenoestrogens.
NP and MBP were more potent xenoestrogens than OP and BPA.
The four xenoestrogens have potential to disrupt androgen-estrogen homoeostasis.