- 作者：Pauline H.B. Kok ; Roy de Kinkelder ; Yvette C. Braaksma-Besselink ; Jeroen Kalkman ; Liesbeth J.J.M. Prick ; Marije L. Sminia ; Maarten Ph. Mourits ; Frank D. Verbraak
- 刊名：Journal of American Association for Pediatric Ophthalmology and Strabismus
- 出版年：December, 2013
- 年：2013
- 卷：17
- 期：6
- 页码：598-602
- 全文大小：247 K
Purpose
To investigate the relationship between retinal thickness and axial length in amblyopic eyes compared to healthy eyes.Methods
In this observational, transversal study, 36 amblyopic children and 30 healthy controls underwent full ophthalmological and orthoptic examinations, volume scanning of the macula with spectral domain optical coherence tomography (3D OCT-1000; Topcon Corporation, Tokyo, Japan), and measuring of axial length using the IOLMaster (Carl聽Zeiss Meditec AG, Jena, Germany). The average pericentral retinal thickness was calculated.
Results
A strong correlation was observed between the axial lengths of both eyes in the control group (R = 0.98, P < 0.01) and between the axial lengths of the amblyopic and fellow eye in the amblyopic group (R = 0.77, P < 0.01); the amblyopic and their fellow eyes were significantly shorter than the nonamblyopic control eyes. The pericentral retinal thickness of both eyes of an individual is highly correlated in nonamblyopic controls (R聽= 0.92, P < 0.01) and in amblyopic children (R = 0.82, P < 0.01). There is no significant difference in mean pericentral retinal thickness between healthy, amblyopic, and fellow聽eyes. In healthy eyes a moderate inverse correlation exists between axial length and pericentral retinal thickness (R = 鈭?.41, P = 0.02); this relationship was not found in the amblyopic eyes or the normal fellow eye.
Conclusions
In this patient cohort, there was an anomalous relation between the axial length and the聽pericentral retinal thickness in both amblyopic and their fellow eyes.