Cigarette smoking and risk of pancreatic cancer: a clinic-based case-control study in the San Francisco Bay Area

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• 作者：C. Suzanne Lea ; PhD ; MPH^a ; ^b ; ^{leac@ecu.edu" class="auth_mail" title="E-mail the corresponding author} ; Elizabeth A. Holly ; PhD ; MPH^b ; Paige M. Bracci ; PhD ; MS ; MPH^b
• 关键词：Pancreatic neoplasms ; Outpatient clinics ; Case-control studies ; Cigarette smoking ; California
• 刊名：Annals of Epidemiology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：25
• 期：11
• 页码：816-823
• 全文大小：443 K

文摘

Cigarette smoking is an established risk factor for pancreatic cancer (PC). We examined the association between cigarette smoking and PC in a San Francisco Bay Area clinic-based, case-control study.

Methods

A total of 536 cases and sex and age frequency-matched controls (n = 869) were recruited predominately from the University of California San Francisco (UCSF) medical clinics between 2006 and 2011. Participants were interviewed in-person using structured questionnaires. Adjusted odds ratios (ORs) were computed.

Results

Forty-eight percent of cases and controls reported never having smoked cigarettes; 39% of cases and 40% of controls were former smokers; 13% of cases and 12% of controls were current smokers. No association was found for either former (OR = 0.85, 95% confidence interval [CI] = 0.66–1.1) or current cigarette smoking (men: OR = 1.0, 95% CI = 0.60–1.7; women: OR = 1.2, 95% CI = 0.73–2.1). No dose-response relationships were detected with number of cigarettes/day, smoking intensity, duration, or years since last smoked. Comparisons with a 1995–1999 population-based UCSF study demonstrated a significantly increased proportion of never smokers in this study (P < .001).

Conclusions

This study revealed no significant associations between cigarette smoking and PC in the San Francisco Bay Area during 2006–2011. Data suggest a reduction in the duration of smoking within the referral population.