Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium

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• 作者：Silvia De Sanjose^?/sup> ; ^{s.sanjose@iconcologia.net} ; Yolanda Benavente^?/sup> ; Claire M. Vajdic^&Dagger ; ; Eric A. Engels^§ ; ; Lindsay M. Morton^§ ; ; Paige M. Bracci^?/sup> ; John J. Spinelli^¶ ; ; Tongzhang Zheng^# ; Yawei Zhang^# ; Silvia Franceschi^?? ; Renato Talamini^&Dagger ; &Dagger ; ; Elizabeth A. Holly^?/sup> ; Andrew E. Grulich^&Dagger ; ; James R. Cerhan^§ ; § ; ; Patricia Hartge^§ ; ; Wendy Cozen^¡Î¡Î ; Paolo Boffetta^?? ; Paul Brennan^?? ; Marc Maynadié ; ^¶ ; ¶ ; ; Pierluigi Cocco^## ; Ramon Bosch^???/sup> ; Lenka Foretova^&Dagger ; &Dagger ; &Dagger ; ; Anthony Staines^§ ; § ; § ; ; Nikolaus Becker^{¡Î¡Î?/sup>} ; Alexandra Nieters^{¡Î¡Î?/sup>}
• 关键词：BLyS ; B-lymphocyte stimulator ; CI ; confidence interval ; DLBCL ; diffuse large B-cell lymphoma ; FL ; follicular lymphoma ; HCV ; hepatitis C virus ; InterLymph ; International Lymphoma Epidemiology Consortium ; LPL ; lymphoplasmacytic lymphoma ; MZL ; marginal zone
• 刊名：Clinical Gastroenterology and Hepatology
• 出版年：2008
• 出版时间：April 2008
• 年：2008
• 卷：6
• 期：4
• 页码：451-458
• 全文大小：395 K

文摘

Background & Aims: Increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin¡¯s lymphoma (NHL) subtypes after HCV infection. Methods: The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded. Results: HCV infection was detected in 172 NHL cases (3.60 % ) and in 169 (2.70 % ) controls (odds ratio [OR], 1.78; 95 % confidence interval [CI], 1.40?.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95 % CI, 1.44?.23), diffuse large B-cell lymphoma (OR, 2.24; 95 % CI, 1.68?.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95 % CI, 1.14?.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95 % CI, 0.65?.60). Conclusions: These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma).