A weight of evidence assessment approach for adverse outcome pathways
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- 作者：Zachary A. Colliera ; zac4nf@virginia.edu" class="auth_mail" title="E-mail the corresponding author ; Kurt A. Gusta ; Benette Gonzalez-Moralesb ; Ping Gonga ; Mitchell S. Wilbanksa ; Igor Linkova ; Edward J. Perkinsa
- 关键词：Adverse outcome pathway ; Weight of evidence ; Quantitative AOP ; Molecular initiating event ; Mode of action ; Key event relationships ; Bradford Hill criteria
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：46-57
- 全文大小：1599 K
文摘
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AOPs conceptually link molecular initiating events and adverse biological outcomes.
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Development of AOPs requires the assessment of their weight of evidence (WoE).
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This paper describes a semi-quantitative method to evaluate WoE for AOPs.
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WoE criteria are based on EPA General Assessment Factors and Bradford Hill criteria.
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Two illustrative case studies are shown to demonstrate the WoE assessment method.