Improved controlled release of protein from expanded-pore mesoporous silica nanoparticles modified with co-functionalized poly(n-isopropylacrylamide) and poly(ethylene glycol) (PNIPAM-PEG)
MSNs with 11 nm pores and gated with PNIPAM were synthesized. Further surface functionalization with PEG in the pores improved BHb release. The inclusion of PEG minimized BHb deformation.