Chaetognath phylogenomics: a protostome with deuterostome-like development

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• 作者：Ferdin ; Marlé ; taz ; Elise Martin ; Yvan Perez ; Daniel Papillon ; Xavier Caubit ; Christopher J. Lowe ; Bob Freeman ; Laurent Fasano ; Carole Dossat ; Patrick Wincker ; Jean Weissenbach ; Yannick Le Parco
• 关键词：CELLCYCLE
• 刊名：Current Biology
• 出版年：2006
• 出版时间：8 August 2006
• 年：2006
• 卷：16
• 期：15
• 页码：R577-R578
• 全文大小：99 K

文摘

Neurons are highly polarized cells with distinct subcellular compartments, including dendritic arbors and an axon. The proper function of the nervous system relies not only on correct targeting of axons, but also on development of neuronal-class-specific geometry of dendritic arbors 1, 2, 3 and 4. To study the intercellular control of the shaping of dendritic trees in vivo, we searched for cell-surface proteins expressed by Drosophila dendritic arborization (da) neurons 5, 6 and 7. One of them was Neuroglian (Nrg), a member of the Ig superfamily [8]; Nrg and vertebrate L1-family molecules have been implicated in various aspects of neuronal wiring, such as axon guidance, axonal myelination, and synapse formation 9, 10, 11 and 12. A subset of the da neurons in nrg mutant embryos exhibited deformed dendritic arbors and abnormal axonal sprouting. Our functional analysis in a cell-type-selective manner strongly suggested that those da neurons employed Nrg to interact with the peripheral glia for suppressing axonal sprouting and for forming second-order dendritic branches. At least for the former role, Nrg functioned in concert with the intracellular adaptor protein Ankyrin (Ank) [13]. Thus, the neuron-glia interaction that is mediated by Nrg, together with Ank under some situations, contributes to axonal and dendritic morphogenesis.