Synthesis of multivalent sialyllactosamine-carrying glyco-nanoparticles with high affinity to the human influenza virus hemagglutinin
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- 作者：Makoto Ogataa ; ogata@fukushima-nct.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Seiichiro Umemurab ; Naohiro Sugiyamab ; Natsuki Kuwanoa ; Ami Koizumia ; Tadakazu Sawadac ; Michiyo Yanased ; Takeshi Takahad ; Jun-ichi Kadokawae ; Taichi Usuif
- 关键词：Carbohydrate ; Cluster effect ; Multivalency ; Nanoparticle ; Influenza virus
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 November 2016
- 年：2016
- 卷：153
- 期：Complete
- 页码：96-104
- 全文大小：1773 K
文摘
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We synthesized sialoglyco-nanoparticles using a spherical nanocluster backbone of sugar units.
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Highly-branched α-glucuronic acid-linked cyclic dextrins were used in the backbone.
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Particles display high-functionalization, low polydispersity and controlled diameter.
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Sialoglyco-nanoparticles exhibited high affinity against human influenza virus hemagglutinin.