Detection of ECG effects of (2R,4R)-monatin, a sweet flavored isomer of a component first identified in the root bark of the Sclerochitin ilicifolius plant
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- 作者：Borje Darpoa ; b ; borje.darpo@icardiac.com" class="auth_mail" title="E-mail the corresponding author ; Thorir D. Bjornssonc ; thorir.bjornsson@verizon.net" class="auth_mail" title="E-mail the corresponding author ; Witty A. Brathwaited ; witty_brathwaite@cargill.com" class="auth_mail" title="E-mail the corresponding author ; Christine M. Crincolie ; christine_crincoli@cargill.com" class="auth_mail" title="E-mail the corresponding author ; Alex K. Eapene ; alex_eapen@cargill.com" class="auth_mail" title="E-mail the corresponding author ; Gerald L. Fisherf ; geraldfisher@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Peter R. Koweyg ; h ; koweyp@mlhs.org" class="auth_mail" title="E-mail the corresponding author ; Marvin P. Millere ; marv_miller@cargill.com" class="auth_mail" title="E-mail the corresponding author ; Andrey I. Nikiforovi ; anikiforov@toxregserv.com" class="auth_mail" title="E-mail the corresponding author ; Marisa O. Rihneri ; mrihner@toxregserv.com" class="auth_mail" title="E-mail the corresponding author ; Meijian Zhoub ; meijian.zhou@icardiac.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：(2R ; 4R)-Monatin ; QT prolongation ; QTc ; TQT study ; Food ingredient
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：217-224
- 全文大小：645 K
文摘
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(2R,4R)-Monatin exists naturally in small quantities in the root bark of the South African plant, Sclerochitin ilicifolius.
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Enzymatically-synthesized (2R,4R)-monatin has been evaluated for potential use as a food ingredient.
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QT internal prolongation was observed in a pharmacokinetic study in 12 healthy males administered 2 mg/kg (2R,4R)-monatin.
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A thorough QTc study was conducted and showed QT prolongation of 25 ms after a single dose of 150 mg (2R,4R)-monatin.
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QTc prolongation at high (2R,4R)-monatin plasma levels is a significant finding.