Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody
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- 作者：Mattia Bonsignori1 ; 2 ; 23 ; Tongqing Zhou3 ; 23 ; Zizhang Sheng4 ; 5 ; 23 ; Lei Chen3 ; 23 ; Feng Gao1 ; 2 ; M. Gordon Joyce3 ; Gabriel Ozorowski6 ; 7 ; 8 ; Gwo-Yu Chuang3 ; Chaim A. Schramm4 ; 5 ; Kevin Wiehe1 ; 2 ; S. Munir Alam1 ; 2 ; Todd Bradley1 ; Morgan A. Gladden1 ; Kwan-Ki Hwang1 ; Sheelah Iyengar1 ; Amit Kumar1 ; Xiaozhi Lu1 ; Kan Luo1 ; Michael C. Mangiapani1 ; Robert J. Parks1 ; Hongshuo Song1 ; Priyamvada Acharya3 ; Robert T. Bailer3 ; Allen Cao3 ; Aliaksandr Druz3 ; Ivelin S. Georgiev3 ; 9 ; 10 ; 11 ; Young D. Kwon3 ; Mark K. Louder3 ; Baoshan Zhang3 ; Anqi Zheng3 ; Brenna J. Hill3 ; Rui Kong3 ; Cinque Soto3 ; NISC Comparative Sequencing Program12
- 刊名：Cell
- 出版年：2016
- 出版时间：7 April 2016
- 年：2016
- 卷：165
- 期：2
- 页码：449-463
- 全文大小：4357 K
文摘
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Developmental pathway of a CD4-mimicking antibody lineage from time of infection
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Maturation involves focused recognition of CD4-binding site of vulnerability
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Intrinsic VH1-46 gene mutability guides somatic mutation of CD4-binding site bnAbs
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Study provided a strategy for inducing both CD4-mimicking and CDR H3-using bnAbs