Decomposition of 1-(ω-aminoalkanoyl)guanidines under alkaline conditions
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- 作者：Albert Brennauer ; Max Keller ; Matthias Freund ; Gü ; nther Bernhardt ; Armin Buschauer
- 关键词：Acylguanidines ; Lactam formation ; Degradation rate ; UV spectroscopy
- 刊名：Tetrahedron Letters
- 出版年：2007
- 出版时间：24 September 2007
- 年：2007
- 卷：48
- 期：39
- 页码：6996-6999
- 全文大小：268 K
文摘
The decomposition of some NG-(ω-aminoalkanoyl)argininamides, which are key intermediates for the preparation of radiolabeled and fluorescent neuropeptide Y receptor ligands, prompted us to synthesize a small series of simple 1-(ω-aminoalkanoyl)guanidines, and to investigate these model compounds for stability in alkaline buffers. The degradation of acylguanidines was monitored by time resolved UV spectroscopy. The most labile compound, 1-(5-aminopentanoyl)guanidine, decomposed with a half life of 19 s to yield piperidin-2-one (pH 10.4 at 25 °C). In contrast the half life of 1-(6-aminohexanoyl)guanidine is 7.7 h, which is comparable to the hydrolysis of acetylguanidine (t1/2 = 9.6 h) in alkaline solution.