Characteristics, treatment, and survival of invasive malignant melanoma (MM) in giant pigmented nevi (GPN) in adults: 976 cases from the National Cancer Data Base (NCDB)

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• 作者：Ashley E. Turkeltaub ; BS^b ; Todd A. Pezzi ; BS^b ; Christopher M. Pezzi ; MD^c ; Harry Dao Jr. ; MD^a ; ^b ; ^{Harry.DaoJr@bcm.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：giant congenital nevi ; giant pigmented nevi ; malignant melanoma ; National Cancer Data Base ; nodular melanoma ; superficial spreading melanoma
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：74
• 期：6
• 页码：1128-1134
• 全文大小：531 K

文摘

Malignant melanoma (MM) arising in a giant pigmented nevus (GPN) is a rare disease in adults with no large series published to our knowledge.

Objective

We sought to describe the characteristics, treatment, and survival of MM in GPN for adults.

Methods

Adults with invasive MM in GPN (n = 976) reported to the National Cancer Data Base from 1998 to 2012 were evaluated for patient and tumor characteristics, treatment, and survival. For comparison, data from adults with invasive superficial spreading melanoma (SSM) (n = 111,870) and nodular melanoma (n = 35,962) were used.

Results

Compared with patients with SSM, patients with MM in GPN had a thicker Breslow depth, more positive lymph nodes, and distant metastasis more frequently. Multivariate analysis identified age older than 65 years, Breslow thickness greater than 2 mm, presence of ulceration, presence of distant metastasis, and positive margins as independent predictors of survival in patients with MM in GPN. At all stages, having MM in GPN has similar overall survival compared with SSM.

Limitations

The study is retrospective and registry-based.

Conclusions

Invasive MM in GPN occurs in adults, with overall survival similar to SSM. Clinicians should be aware of the continued risk of MM in adults with GPN with low threshold for biopsy.