Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts
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- 作者：Benoit Le Goffa ; b ; Sofie Singbranta ; Brett A. Tonkina ; T. John Martina ; c ; Evange Romasc ; d ; Natalie A. Simsa ; c ; Nicole C. Walsha ; c ; nwalsh@svi.edu.au" class="auth_mail
- 关键词：Oncostatin M ; Synovial fibroblast ; IL-1 ; IL-6 ; Arthritis
- 刊名：Cytokine
- 出版年：August 2014
- 年：2014
- 卷：68
- 期：2
- 页码：101-109
- 全文大小：1135 K
文摘
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Synovial tissue expression of OSM, gp130, OSMR and LIFR is increased in arthritis.
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OSM induces synovial fibroblast (SF) expression of IL-6, RANKL, OSMR, gp130, IL-1R.
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OSM action in SFs requires the expression of OSMR.
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OSM augments IL-1尾 induction of IL-6 & RANKL in SFs, by increasing IL-1R expression.
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OSM augments TNF induction of IL-6 but not RANKL expression in SFs.