Pharmacological effects of ethanol extract of Egyptian Artemisia herba-alba in rats and mice

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• 作者：Gehad Abdel Raheem Abdel Jaleel ; Heba Mohammed Ibrahim Abdallah ; ^{hebamohammed2011@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Nawal E.L. Sayed Gomaa
• 关键词：Artemisia herba-alba ; Gastric ulcer ; Inflammation ; Antioxidant ; Rats ; Mice
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：6
• 期：1
• 页码：44-49
• 全文大小：616 K

文摘

To investigate some pharmacological effects including gastroprotective, anti-inflammatory, analgesic, antipyretic and in vitro antioxidant effects of Artemisia herba-alba extract in different experimental models.

Methods

Inflammation was induced in rat paw by subcutaneous injection of 1% (v/v) carrageenan solution. Writhes was induced in mice by intraperitoneal injection of 0.6% (v/v) acetic acid solution. Pyrexia was induced using Brewer's yeast suspension. Gastric lesion was induced in rats by oral administration of 99% ethanol. The anti-inflammatory, analgesic, antipyretic and gastroprotective activities of Artemisia herba-alba extract were investigated respectively. In vitro antioxidant effect was investigated using DPPH free radical.

Results

The plant extract showed anti-inflammatory effect in carrageenan-induced paw edema in rats, analgesic effect against acetic acid-induced writhing, and antipyretic activity in Brewer's yeast model of pyrexia. Besides, it was shown to be a gastroprotective agent against ethanol-induced gastric ulcers. The plant also exhibited a free radical scavenging potential in an in vitro antioxidant study using DPPH.

Conclusions

The results validate the use of the investigated plant in traditional medicine for different ailments.