Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles
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- 作者：Jan Dvořá ; ka ; b ; c ; 1 ; Pavla Fajtová ; c ; d ; Lenka Ulrychová ; a ; e ; Adrian Leontovyčc ; d ; Liliana Rojo-Arreolaf ; Brian M. Suzukif ; 2 ; Martin Hornc ; Michael Mare&scaron ; c ; Charles S. Craikg ; Conor R. Caffreyf ; 2 ; Anthony J. O'Donoghueg ; 2 ; ajodonoghue@ucsd.edu" class="auth_mail" title="E-mail the corresponding author ; ccaffrey@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parasite ; Fluke ; Secretion ; Excretion ; Protease ; Inhibitor
- 刊名：Biochimie
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：99-109
- 全文大小：1799 K
文摘
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Unbiased and global peptidase specificity technology to detect novel activities.
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Excretion/secretion peptidase activity detected in Schistosoma mansoni.
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All stages except cercariae secrete a trypsin-type serine peptidase(s).
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Eggs and adults, but not schistosomula, release metallo-peptidases.
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Eggs release a cysteine protease that is active at neutral pH.