HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets
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- 作者：Yuedan Zhoua ; Nikolay Oskolkova ; Liliya Shcherbinaa ; Joyce Rattib ; Kian-Hong Kockb ; Jing Suc ; Brian Martind ; Malin Zackrisson Oskolkovae ; Olga Gö ; ranssona ; Julie Bacona ; Weimin Lie ; Saskia Bucciarellie ; Corrado Cilioa ; Alvis Brazmac ; Bradley Thatchera ; 1 ; Johan Rungc ; Nils Wierupa ; Erik Renströ ; ma ; Leif Groopa ; Ola Hanssona ; Ola.Hansson@med.lu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：TCF7L2 ; Type 2 diabetes ; HMGB1 ; Chromatin binding
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：430
- 期：Complete
- 页码：138-145
- 全文大小：906 K
文摘
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High-mobility group protein B1 (HMGB1) binds the rs7903146 locus in HCT116 cells.
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HMGB1 binding was confirmed in human pancreatic islets using 2 different methods.
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HMGB1 possibly binds the C-allele with higher affinity compared to the T-allele.
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HMGB1 depletion reduces TCF7L2 mRNA and activity levels.
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HMGB1 depletion reduces insulin expression and glucose stimulated insulin secretion.