A mild and efficient approach to enantioenriched α-hydroxyethyl α,β-unsaturated δ-lactams
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- 作者：Seo-Jung Han ; Brian M. Stoltz ; stoltz@caltech.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：δ-Lactams ; Ring-closing metathesis ; Asymmetric allylation ; Baylis&ndash ; Hillman reaction
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：25 May 2016
- 年：2016
- 卷：57
- 期：21
- 页码：2233-2235
- 全文大小：908 K
文摘
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A mild approach toward α-hydroxyethyl α,β-unsaturated δ-lactams is described.
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The stereochemistry at the δ-position of the lactam was formed by Ellman’s protocol.
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The α,β-unsaturated δ-lactam was smoothly constructed by ring-closing metathesis.
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A Baylis–Hillman reaction afforded the substitution at the α-position of the lactam.