DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants
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- 作者：Vickie Kwan1 ; 2 ; Durga Praveen Meka3 ; Sean H. White1 ; 2 ; Claudia L. Hung2 ; Nicholas T. Holzapfel1 ; 2 ; Susan Walker4 ; 5 ; Nadeem Murtaza1 ; 2 ; Brianna K. Unda1 ; 2 ; Birgit Schwanke3 ; Ryan K.C. Yuen4 ; 5 ; Kendra Habing1 ; 2 ; Chloe Milsom1 ; 2 ; Kristin J. Hope1 ; 2 ; Ray Truant2 ; Stephen W. Scherer4 ; 5 ; Froylan Calderon de Anda3 ; Karun K. Singh1 ; 2 ; 6 ; singhk2@mcmaster.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：dendrite growth ; dendritic spine ; autism spectrum disorder ; actin ; cytoskeleton ; neurodevelopment ; genetic variants ; MARK1 ; excitatory synapse ; Wnt signaling
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：8 November 2016
- 年：2016
- 卷：17
- 期：7
- 页码：1892-1904
- 全文大小：4251 K
文摘
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DIXDC1 is a regulator of dendrite and spine development
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MARK1 phosphorylates DIXDC1 isoforms to regulate dendrite and spine development
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Phosphorylation of DIXDC1 isoform 1 regulates cytoskeletal dynamics
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ASD variants in DIXDC1 isoform 1 impair phosphorylation and neuronal morphology