N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer
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- 作者：Etienne Dardenne1 ; 11 ; Himisha Beltran2 ; 3 ; 4 ; 11 ; Matteo Benelli5 ; Kaitlyn Gayvert6 ; 7 ; Adeline Berger1 ; Loredana Puca4 ; Joanna Cyrta1 ; 4 ; Andrea Sboner1 ; 4 ; 6 ; 7 ; Zohal Noorzad1 ; Theresa MacDonald1 ; Cynthia Cheung1 ; Ka Shing Yuen1 ; Dong Gao8 ; Yu Chen3 ; 8 ; 9 ; Martin Eilers10 ; Juan-Miguel Mosquera1 ; 4 ; Brian D. Robinson1 ; 4 ; Olivier Elemento2 ; 4 ; 6 ; Mark A. Rubin1 ; 2 ; 4 ; 6 ; Francesca Demichelis4 ; 5 ; David S. Rickman1 ; 2 ; 4 ; 12 ; dsr2005@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：neuroendocrine prostate cancer ; N-Myc ; EZH2 ; Aurora kinase A ; castration-resistant prostate adenocarcinoma ; genetically engineered mouse ; prostate cancer organoid
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：30
- 期：4
- 页码：563-577
- 全文大小：6102 K
文摘
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N-Myc drives the NEPC phenotype and associated molecular program
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N-Myc abrogates AR signaling, which results in enhanced AKT activity
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N-Myc redirects EZH2 activity and sensitizes cells to EZH2 inhibitors
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N-Myc interacts with Aurora-A, which facilitates N-Myc target gene expression