Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b
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- 作者：Mark E. Schnute ; Roger J. Brideau ; Sarah A. Collier ; Michele M. Cudahy ; Todd A. Hopkins ; Mary L. Knechtel ; Nancee L. Oien ; Robert S. Sackett ; Allen Scott ; Mari L. Stephan ; Michael W. Wathen ; Janet L.
- 关键词：Cytomegalovirus ; HCMV ; Varicella-zoster ; VZV ; HSV ; EBV
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2008
- 出版时间：15 July 2008
- 年：2008
- 卷：18
- 期：14
- 页码：3856-3859
- 全文大小：253 K
文摘
A versatile synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxylate esters has been developed which has lead to the identification of a new series of non-nucleoside inhibitors of human herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.