Lactate detection in the brain of growth-restricted fetuses with magnetic resonance spectroscopy

详细信息    查看全文

• 作者：Irene Cetin ; MD ; PhD^b ; ^e ; Barbara Barberis ; PhD^a ; Valentina Brusati ; MD^b ; Erika Brighina ; MD^a ; ^c ; Luca Mandia ; MD^b ; ^e ; Andrea Arighi ; MD^a ; ^c ; Tatjana Radaelli ; MD^b ; ^d ; Pietro Biondetti ; MD^a ; Nereo Bresolin ; MD^a ; ^c ; Giorgio Pardi ; MD^b ; ^d ; Mario Rango ; MD ; PhD^a ; ^c ; ^{mariocristia@yahoo.it}
• 关键词：brain sparing ; fetal brain metabolism ; fetal distress ; placental insufficiency ; pregnancy
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2011
• 出版时间：October, 2011
• 年：2011
• 卷：205
• 期：4
• 页码：350.e1-350.e7
• 全文大小：516 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferencesersion=""1.0"" encoding=""UTF-8""?>

Objective

The objective of the study was to determine the feasibility of detecting fetal brain lactate, a marker of fetal metabolic acidemia, using a noninvasive technique, proton magnetic resonance spectroscopy (¹H MRS), in intrauterine growth-restricted (IUGR) fetuses.

Study Design

In vivo human fetal brain lactate detection was determined by ¹H MRS in 5 fetuses with IUGR. Oxygenation and acid-base balance data were obtained at birth.

Results

¹H MRS analysis showed the presence of a lactate peak in the brain of the most severely affected IUGR fetus, with abnormal umbilical artery Doppler and fetal heart rate tracing. This finding was consistent with the low oxygen content and high lactic acid concentration observed in umbilical blood obtained at delivery.

Conclusion

¹H MRS allows the noninvasive detection of cerebral lactate in IUGR fetuses. Lactate detected by ¹H MRS may represent a possible marker of in utero cerebral injury or underperfusion.