The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants

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• 作者：Michael G. Heckman ; Alexis Elbaz ; Alex ; ra I. Soto-Ortolaza ; Daniel J. Serie ; Jan O. Aasly ; Grazia Annesi ; Georg Auburger ; Justin A. Bacon ; Magdalena Boczarska-Jedynak ; Maria Bozi ; Laura Brighina ; Marie-Christine Chartier-Harlin ; Efthimios Dardiotis ; Alain Dest¨¦e ; Carlo Ferrarese ; Aless ; ro Ferraris ; Brian Fiske ; Suzana Gispert ; Georgios M. Hadjigeorgiou ; Nobutaka Hattori ; et al.
• 关键词：Parkinson's disease ; LRRK2 ; SNCA ; MAPT ; Interaction ; Genetics
• 刊名：Neurobiology of Aging
• 出版年：2014
• 出版时间：January, 2014
• 年：2014
• 卷：35
• 期：1
• 页码：266.e5-266.e14
• 全文大小：753 K

文摘

The best validated susceptibility variants for Parkinson's disease are located in the ¦Á-synuclein (<em>SNCAem>) and microtubule-associated protein tau (<em>MAPTem>) genes. Recently, a protective p.N551K-R1398H-K1423K haplotype in the leucine-rich repeat kinase 2 (<em>LRRK2)em> gene was identified, with p.R1398H appearing to be the most likely functional variant. To date, the consistency of the protective effect of LRRK2 p.R1398H across <em>MAPTem> and <em>SNCAem> variant genotypes has not been assessed. To address this, we examined 4 <em>SNCAem> variants (rs181489, rs356219, rs11931074, and rs2583988), the <em>MAPTem> H1-haplotype-defining variant rs1052553, and LRRK2 p.R1398H (rs7133914) in Caucasian (n?= 10,322) and Asian (n?= 2289) series. There was no evidence of an interaction of LRRK2 p.R1398H with <em>MAPTem> or <em>SNCAem> variants (all <em>pem> ¡Ý 0.10); the protective effect of p.R1398H was observed at similar magnitude across <em>MAPTem> and <em>SNCAem> genotypes, and the risk effects of <em>MAPTem> and <em>SNCAem> variants were observed consistently for LRRK2 p.R1398H genotypes. Our results indicate that the association of LRRK2 p.R1398H with Parkinson's disease is independent of <em>SNCAem> and <em>MAPTem> variants, and vice versa, in Caucasian and Asian populations.