Antioxidant efficacy of iridoid and phenylethanoid glycosides from the medicinal plant Teucrium chamaedris

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• 作者：Severina Pacifico ; Brigida D’ ; Abrosca ; Maria Teresa Pascarella ; Marianna Letizia ; Piera Uzzo ; Vincenzo Piscopo ; Antonio Fiorentino
• 关键词：Teucrium chamaedrys ; Iridoid glycosides ; Phenylethanoid glycosides ; NMR analysis ; Antioxidant activity ; Cell-free systems
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2009
• 出版时间：1 September 2009
• 年：2009
• 卷：17
• 期：17
• 页码：6173-6179
• 全文大小：483 K

文摘

Twelve glycosides, seven iridoids and five phenylethanoids, have been isolated from leaf and root methanolic extracts of Wall Germander (Teucrium chamaedrys), a Mediterranean species historically used as a medicinal plant. Among them, three iridoid and one phenylethanoid glycosides have been isolated and characterized for the first time. All of the structures have been elucidated on the basis of their spectral data, especially 1D and 2D NMR experiments.

The antioxidative properties of pure metabolites, as well as of crude organic extracts of the plant, have been analyzed on the basis of their DPPH radical scavenging capability. The antioxidant capacity in cell-free systems of the isolated metabolites was carried out by measuring their capabilities to inhibit the synthesis of thiobarbituric acid reactive species in assay media using as oxidable substrates a vegetable fat and the pentose sugar 2-deoxyribose and to prevent oxidative damage of the hydrosoluble bovine serum albumin (BSA) protein. Phenylethanoid glycosides resulted efficacious DPPH radical, while iridoid glycosides prevent massively the 2-deoxyribose and BSA oxidations in assay media.