Spectroscopic identification and anti-biofilm properties of polar metabolites from the medicinal plant Helichrysum italicum against Pseudomonas aeruginosa

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• 作者：Brigida D¡¯Abrosca ; Elisabetta Buommino ; Grazia D¡¯Angelo ; Lorena Coretti ; Monica Scognamiglio ; Valeria Severino ; Severina Pacifico ; Giovanna Donnarumma ; Antonio Fiorentino
• 关键词：Helichrysum italicum ; Structural characterization ; Spectroscopic analysis ; Anti-biofilm activity ; Pseudomonas aeruginosa
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2013
• 出版时间：15 November, 2013
• 年：2013
• 卷：21
• 期：22
• 页码：7038-7046
• 全文大小：609 K

文摘

Two new acylated styrylpyrones, one 5-methoxy-1(3H)-isobenzofuranone glucoside and a hydroxymethyl-orcinol derivative, along with sixteen known aromatic metabolites, including lignans, quinic acid derivatives low-molecular weight phenol glucosides, have been isolated from the methanol extract of Helichrysum italicum, a medicinal plant typical of the Mediterranean vegetation. The structures of these compounds have been elucidated on the basis of extensive 2D-NMR spectroscopic analyses, including COSY, TOCSY, HSQC, CIGAR-HMBC, H2BC and HSQC-TOCSY, along with Q-TOF HRMS² analysis. Selected compounds were evaluated for their anti-biofilm properties against Pseudomonas aeruginosa.