Long term study of deoxyribozyme administration to XT-1 mRNA promotes corticospinal tract regeneration and improves behavioral outcome after spinal cord injury
详细信息 查看全文
- 作者：Brigitte Koeniga ; Brigitte.Koenig@uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Daniel Papeb ; Daniel.Pape@med.uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Owen Chaoc ; owenchao@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jordana Bauerb ; jordana.bauer@googlemail.com" class="auth_mail" title="E-mail the corresponding author ; Barbara Grimpeb ; d ; bgrimpe@hotmail.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT ; 5-hydroxytryptamine ; ANOVA ; analysis of variance ; as ; antisense ; AAV ; adeno-associated virus ; BBB ; Basso ; Beattie ; Bresnahan ; BDA ; biotinylated dextran amine ; BSA ; bovine serum albumin ; C ; Celsius ; cDNA ; complementary deoxyribonucleic acid ; CGRP ; calcitonin gene-related peptide ; ChABC ; chondroitinase ABC ; cm ; centimeter ; CNS ; central nervous system ; CS-PG ; chondroitin sulfate proteoglycans ; CST ; cortical spinal tract ; DRG ; dorsal root ganglion ; dT ; deoxythymine ; EGFR ; epidermal growth fact
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：276
- 期：Complete
- 页码：51-58
- 全文大小：951 K
文摘
- •
Investigation of long term effects after DNA enzyme to XT-1 mRNA delivery
- •
Reduced XT-1 mRNA level after a dorsal hemisection of the spinal cord
- •
Improved behavioral outcome
- •
Growth of CST axons
- •
Tissue protection after 19 weeks