Treatment with Sunitinib Enabled Complete Resection of Massive Lymphadenopathy not Previously Amenable to Excision in a Patient with Renal Cell Carcinoma

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• 作者：Jean-Jacques Patard ; Rodolphe Thuret ; Avakian Raffi ; Brigitte Laguerre ; Karim Bensalah ; Sté ; phane Culine
• 关键词：Complete resection ; Cytoreductive therapy ; Lymphadenopathy ; Renal cell carcinoma ; Sunitinib ; Tyrosine kinase inhibitor ; Unresectable
• 刊名：European Urology
• 出版年：2009
• 出版时间：January 2009
• 年：2009
• 卷：55
• 期：1
• 页码：237-239
• 全文大小：617 K

文摘

We present a case of previously unresectable lymphadenopathy in a patient with renal cell carcinoma treated with sunitinib. Complete resection of a 15-cm left renal cell carcinoma was initially impossible due to massive retroperitoneal disease and encasement of the great vessels and mesenteric vessels. Residual retroperitoneal disease from a radical nephrectomy was treated with the oral, multitargeted receptor tyrosine kinase inhibitor, sunitinib. Tumour shrinkage following five cycles of treatment allowed uncomplicated complete resection of the lymphadenopathy. Follow-up after 6 mo showed no evidence of disease recurrence.