Concomitant Chemoradiotherapy Using Carboplatin, Tegafur-Uracil and Leucovorin for Stage III and IV Head-and-Neck Cancer: Results of GORTEC Phase II Study

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• 作者：Melanie Fesneau ; Yoann Pointreau ; Sophie Chapet ; Laurent Martin ; Pascal Pommier ; Marc Alfonsi ; Brigitte Laguerre ; Nasreddine Feham ; Christine Berger ; Pascal Garaud ; Gilles Calais
• 刊名：International Journal of Radiation Oncology*Biology*Physics
• 出版年：2010
• 出版时间：January 2010
• 年：2010
• 卷：76
• 期：1
• 页码：154-163
• 全文大小：227 K

文摘

Purpose

Concomitant chemoradiotherapy is the standard treatment of locally advanced, nonresectable, head-and-neck squamous cell carcinoma. However, the optimal chemotherapy regimen is still controversial. The objective of this Phase II study was to evaluate the feasibility and efficacy of a concomitant treatment using tegafur-uracil, leucovorin, carboplatin, and radiotherapy.

Methods and Materials

A total of 77 patients with head-and-neck squamous cell carcinoma Stage III and IVA were enrolled between October 2003 and July 2005. Of the 77 patients, 72 were eligible. They were treated with tegafur-uracil (300 mg/m²/d) and leucovorin (75 mg/d) from Days 1 to 19 and from Days 29 to 47 and carboplatin (70 mg/m² intravenously for 4 consecutive days), in three cycles every 21 days. Conventional radiotherapy was delivered to a total dose of 70 Gy in 35 fractions.

Results

With a mean follow-up of 22.8 months, the 3-year locoregional control, overall survival and disease-free survival actuarial rate was 33.1 % , 41.9 % , and 27.2 % , respectively. The compliance of the treatment was correct. The main acute toxicity was mucositis, with 62 % Grade 3-4. Three patients (4.2 % ) died of acute toxicity. The incidence and severity of late toxicity was acceptable, with 32 % Grade 3 and no Grade 4 toxicity.

Conclusion

The protocol of concomitant chemoradiotherapy using tegafur-uracil, leucovorin, and carboplatin for locally advanced unresectable head-and-neck squamous cell carcinoma is feasible. The compliance was correct. The incidence and severity of the acute and late toxicities were acceptable, but not improved. The efficacy of this regimen seems equivalent to the main protocols of concurrent chemoradiotherapy. It represents a possible alternative for patients without an intravenous catheter.