NADPH oxidase 4 deficiency leads to impaired wound repair and reduced dityrosine-crosslinking, but does not affect myofibroblast formation
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- 作者：Dominik Lé ; vignea ; dominik@levigne.eu" class="auth_mail" title="E-mail the corresponding author ; Ali Modarressia ; Karl-Heinz Krauseb ; Brigitte Pittet-Cué ; noda
- 关键词：NADPH oxidase 4 ; Dityrosine crosslinking ; Wound healing ; Wound repair ; HIF1alpha ; CD31 ; Myofibroblast ; Mouse model ; Neovascularization ; ROS ; MPO ; NOX2 ; Collagen crosslinking ; Extracellular matrix ; NOX4 ; VPO1 ; Myeloperoxidase
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：374-384
- 全文大小：3502 K
文摘
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NADPH oxidase 4 is a key element for cutaneous wound repair.
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NADPH oxidase 4 meditates dityrosine cross linking during wound repair.
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NADPH oxidase 4 meditates HIF1alpha expression and angiogenesis during wound repair.
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First evidence for a physiological role of dityrosine crosslinking in higher animals.