Estrogen Receptor ¦Á (ER¦Á) and Estrogen Related Receptor ¦Á (ERR¦Á) are both transcriptional regulators of the Runx2-I isoform

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• 作者：Martial Kammererp>1p>p> ; p>p>2p> ; Sabine Gutzwillerp>1p> ; Daniela Stauffer ; Isabelle Delhon ; Yves Seltenmeyer ; Brigitte Fournierp> ; p>p>brigitte.fournier@novartis.comp>
• 关键词：Estrogen receptor ; Estrogen Related Receptor ¦Á ; Runx2 ; PPAR¦Ã coactivator-1 ; Breast cancer ; Bone metabolism
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2013
• 出版时间：30 April, 2013
• 年：2013
• 卷：369
• 期：1-2
• 页码：150-160
• 全文大小：1124 K

文摘

Runx2 is a master regulator of bone development and has also been described as an oncogene. Estrogen Receptor ¦Á (ER¦Á) and Estrogen Related Receptor ¦Á (ERR¦Á), both implicated in bone metabolism and breast cancer, have been shown to share common transcriptional targets. Here, we show that ER¦Á is a positive regulator of Runx2-I transcription. Moreover, ERR¦Á can act as a transcriptional activator of Runx2-I in presence of peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1¦Á). In contrast, ERR¦Á behaves as a negative regulator of Runx2-I transcription in presence of PGC-1¦Â. ER¦Á and ERR¦Á cross-talk via a common estrogen receptor response element on the Runx2-I promoter. In addition, estrogen regulates PGC-1¦Â that in turn is able to modulate both ER¦Á and ERR¦Á transcriptional activity.