IL-10/IFNγ co-expressing CD4<sup>+sup> T cells induced by IL-10 DC display a regulatory gene profile and downmodulate T cell responses
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- 作者：Martine A. Boks ; Judith R. Kager-Groenland ; S. Marieke van Ham ; Anja ten Brinke<sup> ; sup><sup>a.tenbrinke@sanquin.nl" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Tolerogenic dendritic cells ; Cytokines ; Regulatory T cells ; Micro array ; Suppression ; T helper cell plasticity
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：162
- 期：Complete
- 页码：91-99
- 全文大小：952 K
文摘
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IL-10<sup>+sup> T cells induced by IL-10 dendritic cells co-express IFNγ
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IL-10<sup>+sup>/IFNγ<sup>+sup> T cells display a regulatory gene profile
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IL-10<sup>+sup>/IFNγ<sup>+sup> T cells show a strong regulatory function
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GARP and PD-1 are potential markers for IL-10 DC-induced IL-10<sup>+sup>/IFNγ<sup>+sup> T cells