miR-125b affects mitochondrial biogenesis and impairs brite adipocyte formation and function
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- 作者：Maude Giroud1 ; Didier F. Pisani1 ; Michael Karbiener2 ; Valentin Barquissau3 ; 4 ; Rayane A. Ghandour1 ; Daniel Tews5 ; Pamela Fischer-Posovszky5 ; Jean-Claude Chambard1 ; Uwe Knippschild6 ; Tarja Niemi7 ; Markku Taittonen7 ; Pirjo Nuutila7 ; 8 ; Martin Wabitsch5 ; Stephan Herzig9 ; 10 ; 11 ; 12 ; Kirsi A. Virtanen7 ; 13 ; Dominique Langin3 ; 4 ; 14 ; Marcel Scheideler9 ; 10 ; 11 ; 12 ; Ez-Zoubir Amri1 ; amri@unice.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-125b-5p ; White adipocyte ; Brite adipocyte ; Mitochondriogenesis
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：5
- 期：8
- 页码：615-625
- 全文大小：2541 K
文摘
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miR-125b-5p levels negatively correlate with UCP1 expression in rodent and human.
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miR125b levels in white adipose tissue are positively correlated with BMI.
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miR-125b-5p modulates oxygen consumption.
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Mitochondriogenesis is controlled by miR-125b-5p.
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In vivo modulation of miR-125b-5p controls brown and brite adipocyte formation.