Crown-rump length in chromosomally abnormal fetuses at 10 to 13 weeks' gestation

详细信息    查看全文

• 作者：Peter Kuhn ; Maria de Lourdes Brizot ; Pranaw P. P ; ya ; Rosalinde J. Snijders ; Kypros H. Nicolaides
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：1995
• 出版时间：January 1995
• 年：1995
• 卷：172
• 期：1, Part 1
• 页码：32-35
• 全文大小：726 K

文摘

OBJECTIVE: Our purpose was to investigate whether fetuses with aneuploidies demonstrate evidence of growth retardation during the first trimester.

STUDY DESIGN: This was a retrospective, cross-sectional study of singleton pregnancies undergoing fetal karyotyping at 10 to 13 weeks' gestation. Measurements of crown-rump length in 135 chromosomally abnormal fetuses were compared with those in 700 chromosomally normal fetuses.

RESULTS: The median crown-rump length of fetuses with trisomy 18 (n = 32) was significantly reduced. In contrast, in fetuses with trisomy 21 (n = 72), trisomy 13 (n = 11), 47,XXX (n = 6), 47,XXX (n = 6), 45,X (n = 5), and triploidy (n = 3) the crown-rump length was not lower than normal.

CONCLUSION: At 10 to 13 weeks' gestation fetuses with trisomy 18 are growth retarded, whereas in trisomy 21, trisomy 13, and sex chromosome aneuploidy growth is normal.