The role of 5-HT_1B and 5-HT_1D receptors in the selective inhibitory effect of naratriptan on trigeminovascular neurons

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• 作者：Donaldson ; Cathy ; Boers ; Peter Michael ; Hoskin ; Karen Lisa ; Zagami ; Alessandro Stefano ; Lambert ; Geoffrey Andrew
• 关键词：Trigeminovascular ; Cat ; Migraine ; Naratriptan ; SB224289 ; BRL15572 ; 5-HT_1B/1D receptors
• 刊名：Neuropharmacology
• 出版年：2002
• 出版时间：March, 2002
• 年：2002
• 卷：42
• 期：3
• 页码：374-385
• 全文大小：165 K

文摘

The importance of 5-HT_1B and 5-HT_1D receptors in the actions of the anti-migraine drug naratriptan was investigated using the relatively selective 5-HT₁ receptor ligands SB224289 and BRL15572. Electrical stimulation of the superior sagittal sinus (SSS) in cats activated neurones in the trigeminal nucleus caudalis. Facial receptive fields (RF) were also electrically stimulated to activate the same neurones. Responses of these neurones to SSS stimulation were suppressed by iontophoretic application of naratriptan (5–50 nA). There were two distinct populations of neurones in the nucleus—those in deeper laminae in which the responses to SSS and RF stimulation were equally suppressed by naratriptan (‘non-selective’) and more superficial neurones in which only the SSS responses were suppressed by naratriptan (‘selective’).