Expression of c-Fos protein in medial septum/diagonal band of Broca and CA3 region, associated with the temporary inactivation of the supramammillary area
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Cell activity in the medial septum/diagonal band of Broca and CA3 region of the hippocampus was studied when the SuM area was inactivated.

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It was noted that the temporary inactivation of the SuM area by microinjections of tetrodotoxin, produces hyperactivity in the medial septum/diagonal band of Broca and hypoactivity in the CA3 region of the hippocampus.

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These data suggested that information input to CA3 region of the hippocampus by the SuM area is especially important for good memory/spatial learning functioning.

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