Cell activity in the medial septum/diagonal band of Broca and CA3 region of the hippocampus was studied when the SuM area was inactivated.
It was noted that the temporary inactivation of the SuM area by microinjections of tetrodotoxin, produces hyperactivity in the medial septum/diagonal band of Broca and hypoactivity in the CA3 region of the hippocampus.
These data suggested that information input to CA3 region of the hippocampus by the SuM area is especially important for good memory/spatial learning functioning.