Bromobenzene-induced lethal toxicity in mouse is prevented by pretreatment with zinc sulfate
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- 作者：Hiroki Yoshiokaa ; b ; h-yoshioka@kinjo-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Shiori Fukayaa ; Nobuyuki Fukuishia ; Akito Nagatsua ; Tsunemasa Nonogakia ; Satomi Onosakab
- 关键词：Bromobenzene ; Oxidative stress ; Metallothionein ; Liver ; Kidney
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 July 2016
- 年：2016
- 卷：254
- 期：Complete
- 页码：117-123
- 全文大小：1740 K
文摘
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Protective effect of zinc against bromobenzene-induced toxicity was evaluated.
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Pretreatment with zinc prevented lethal toxicity, blood function markers, and histological changes in both the liver and kidney.
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Prophylaxis with Zinc protects mice from bromobenzene-induced acute toxicity, presumably by induction of metallothionein.