Synthesis of chiral S,N-thioimidazoline ligands for palladium-catalyzed asymmetric allylic alkylations

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• 作者：Xin-Qi Hao ; Ming-Zhan Shen ; Ning-Ge Jian ; Wei Pang ; Xiao-Jing Shen ; Xinju Zhu ; ^{zhuxinju@zzu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Mao-Ping Song ; ^{mpsong@zzu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Tetrahedron: Asymmetry
• 出版年：2016
• 出版时间：15 March 2016
• 年：2016
• 卷：27
• 期：4-5
• 页码：163-170
• 全文大小：786 K

文摘

A series of chiral S,N-thioimidazoline ligands have been synthesized using 2-bromobenzoic acid or 1-bromo-2-naphthoic acid as starting materials. The obtained ligands were evaluated in the Pd-catalyzed asymmetric allylic alkylations and exhibited high catalytic efficiency: yields of up to 94% and enantioselectivities of up to 86% were achieved under the optimized conditions.