Design and baseline characteristics of participants in the study of antihypertensive therapy in children and adolescents with autosomal dominant polycystic kidney disease (ADPKD)

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• 作者：Melissa A. Cadnapaphornchai ; Godela M. Fick-Brosnahan ; Irene Duley ; Ann M. Johnson ; John D. Strain ; Curt G. DeGroff ; Robert W. Schrier
• 关键词：Autosomal dominant polycystic kidney disease ; Hypertension ; Angiotensin converting enzyme inhibition
• 刊名：Contemporary Clinical Trials
• 出版年：2005
• 出版时间：April 2005
• 年：2005
• 卷：26
• 期：2
• 页码：211-222
• 全文大小：126 K

文摘

In this manuscript, we describe our ongoing randomized clinical trial to assess the efficacy of blood pressure control with angiotensin converting enzyme (ACE) inhibition on renal cyst growth over a 5-year study period in children and young adults aged 4–21 years with autosomal dominant polycystic kidney disease (ADPKD). Baseline demographic and laboratory data for the study groups are reported. Results of this study could significantly impact the standard of care for management of ADPKD in this population.