Dectin-1 plays a redundant role in the immunomodulatory activities of?¦Â-glucan-rich ligands in vivo

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• 作者：Mohlopheni J. Marakalala^a ; David L. Williams^b ; Jennifer C. Hoving^a ; Rolf Engstad^c ; Mihai G. Netea^d ; Gordon D. Brown^a ; ^e ; ^{gordon.brown@abdn.ac.uk}
• 关键词：Innate immunity ; Immunomodulation ; Dectin-1 ; Beta-glucan ; MODS ; Staphylococcus aureus
• 刊名：Microbes and Infection
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：15
• 期：6-7
• 页码：511-515
• 全文大小：587 K

文摘

¦Â-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified ¦Â-glucans to mediate protection against systemic Staphylococcus aureus infection in mice. In the second model, we explored the role of Dectin-1 in zymosan induced multiple organ dysfunction syndrome. In both cases, these ¦Â-glucan rich compounds had marked effects in?vivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models.