- 作者：Mois茅s Rodr铆guez-Ma帽ero ; Rub茅n Casado-Arroyo ; Andrea Sarkozy ; Eva Leysen ; Juan Antonio Sieira ; Mehdi Namdar ; Gulio Conte ; Mois茅s Levinstein ; Gian-Battista Chierchia ; Carlo de Asmundis ; Pedro Brugada
- 关键词：DAI ; desfibrilador automá ; tico implantable ; ECG ; electrocardiograma ; EEF ; estudio electrofisioló ; gico ; MSC ; muerte sú ; bita cardiaca ; SB ; sí ; ndrome de Brugada ; SMSI ; sí ; ndrome de muerte sú ; bita infantil
- 刊名：Revista Espa?ola de Cardiología
- 出版年：March, 2014
- 年：2014
- 卷：67
- 期：3
- 页码：176-180
- 全文大小：194 K
Introduction and objectives
Little is known about the risks and outcomes of pregnancy in women with Brugada syndrome. We therefore evaluated pregnancy outcomes and the influence of pregnancy in patients with Brugada syndrome.
Methods
A retrospective analysis was performed in all pregnant women with Brugada syndrome. We included 104 women with a total of 219 deliveries.
Results
There were 15 spontaneous abortions. One infant died suddenly during the night 3 months after birth. Six pregnant women reported they had experienced at least 1 syncope during the pregnancy. Of the 3 women who received an implantable cardioverter-defibrillator before the pregnancy, none received arrhythmia episodes. There were no events during the pregnancy in 4 patients with a previously aborted sudden cardiac death. Of 24 patients with syncope when not pregnant, 18 were asymptomatic and 6 experienced a recurrent syncope during the pregnancy. During the follow-up (mean follow-up 298.9 days; 95% confidence interval, 289.6-308.2), 2 women received appropriate shocks.
Conclusions
In this retrospective, single-center study, serious events were not more frequent during pregnancy and the peripartum period in women with Brugada syndrome. The occurrence of syncope during pregnancy was not associated with a worst outcome in the peri- and postpartum periods or during follow-up. The reported rate of miscarriage and sudden infant death will require further studies to confirm or rule out its association with Brugada syndrome.
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