A chronic, loo
se con
striction of the
sciatic nerve in rat produce
s behavioral
sign
s of
spontaneou
s pain and cutaneou
s hyperalge
sia (Bennett and Xie, Pain, 33 (1988) 87&nda
sh;107) a
s well a
s an abnormal
spontaneou
s activity and adrenergic
sen
sitivity of certain dor
sal root ganglion (DRG) cell
s with axon
s in the injured nerve (Kajander et al., Neuro
sci. Lett., 138 (1992) 225&nda
sh;228; Xie et al., J. Neurophy
siol., 73 (1995)1811&nda
sh;1820) The pre
sent
study inve
stigated whether the
spontaneou
s activity and adrenergic
sen
sitivity were intrin
sic propertie
s of injured DRG cell
s and manife
sted in vitro, i.e., not dependent on intact blood circulation and an intact, functioning
sympathetic nervou
s sy
stem. Two week
s after a loo
se con
striction of the
sciatic nerve, the L4 or L5 DRG with it
s ligated nerve and dor
sal root attached wa
s removed from the rat and placed in a chamber. Extracellular recording
s were made from tea
sed dor
sal root fiber
s. Spontaneou
s activity (>0.05 imp/
s in 3 min) originating within or clo
se to the DRG wa
s often found in C-, A
δ- and A
β-fiber
s from nerve-injured rat
s, but wa
s rare in fiber
s with peripheral axon
s from uninjured nerve. The incidence of variou
s pattern
s of
spontaneou
s di
scharge wa
s similar to that previou
sly recorded in vivo. Nineteen of 30 C-fiber
s, four of five A
δ- and three of
seven A
β-fiber
s from injured nerve re
sponded to different do
se
s of norepinephrine (NE) applied topically to the DRG. Five of
seven C- and one of two A
β-fiber
s from injured nerve re
sponded to clonidine, a more
selective
α<
sub>2
sub> adrenergic agoni
st. The thre
shold
s ranged from 500 to 10
μM, the lowe
st do
se delivered. None of the fiber
s from uninjured nerve re
sponded to NE or clonidine (500
μM). Since the experiment
s were carried out in vitro in the intact DRG, the exi
stence of
spontaneou
s activity in DRG cell
s in nerve-injured rat
s wa
s independent of any blood borne chemical
s,
such a
s norepinephrine. We hypothe
size that abnormal activity and adrenergic
sen
sitivity in injured DRG neuron
s are due to an intrin
sic alteration of the cell body membrane.
size=""-1"" color=""black""> Publisher: | size=""-1"" color=""black""> Elsevier Science |
size=""-1"" color=""black""> Language of Publication: | size=""-1"" color=""black""> English |
size=""-1"" color=""black""> Item Identifier: | size=""-1"" color=""black""> S0304-3959(97)00013-4 |
size=""-1"" color=""black""> Publication Type: | size=""-1"" color=""black""> Article |
size=""-1"" color=""black""> ISSN: | size=""-1"" color=""black""> 0304-3959 |
size=""-1"" color=""black""> Cited by: | size=""-1"" color=""black""> - Kim, Dong-Sun; Yoon, Chul-Ho; Lee, Sang-Ji; Park, So-Yun; Yoo, Hea-Jin; Cho, Hee-Jung,""Changes in voltage-gated calcium channel a<sub>1sub> gene expression in rat dorsal root ganglia following peripheral nerve injury""Molecular Brain Research2001pp. 151-156
sciserv.pl?collection=journals&journal=0169328x&issue=v96i1-2&article=151_civccgrgfpni"">Bibliographic Pagesciserv.pl?collection=journals&journal=0169328x&issue=v96i1-2&article=151_civccgrgfpni&form=pdf&file=file.pdf"">Full Text - Xie, Jiangang; Ho Lee, Young; Wang, Chen; Mo Chung, Jin; Chung, Kyungsoon,""Differential expression of alpha1-adrenoceptor subtype mRNAs in the dorsal root ganglion after spinal nerve ligation""Molecular Brain Research2001pp. 164-172
sciserv.pl?collection=journals&journal=0169328x&issue=v93i0002&article=164_deoasmrgasnl"">Bibliographic Pagesciserv.pl?collection=journals&journal=0169328x&issue=v93i0002&article=164_deoasmrgasnl&form=pdf&file=file.pdf"">Full Text - Hu, San-Jue; Song, Xue-Jun; Greenquist, Kenneth W.; Zhang, Jun-Ming; LaMotte, Robert H.,""Protein kinase A modulates spontaneous activity in chronically compressed dorsal root ganglion neurons in the rat""Pain2001pp. 39-46
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sciserv.pl?collection=journals&journal=00319384&issue=v78i0002&article=241_saepitcimonp"">Bibliographic Pagesciserv.pl?collection=journals&journal=00319384&issue=v78i0002&article=241_saepitcimonp&form=pdf&file=file.pdf"">Full Text - Gonzalez, J.A.; Bellorin, A.; Guerrero, L.E.,""How to excite the internal modes of sine-Gordon solitons""Chaos, Solitons and Fractals2003pp. 907-919
sciserv.pl?collection=journals&journal=09600779&issue=v17i0005&article=907_htetimoss"">Bibliographic Pagesciserv.pl?collection=journals&journal=09600779&issue=v17i0005&article=907_htetimoss&form=pdf&file=file.pdf"">Full Text - Song, Xue-Jun; Zhang, Jun-Ming; Hu, San-Jue; LaMotte, Robert H.,""Somata of nerve-injured sensory neurons exhibit enhanced responses to inflammatory mediators""Pain2003pp. 701-709
sciserv.pl?collection=journals&journal=03043959&issue=v104i0003&article=701_sonsneertim"">Bibliographic Pagesciserv.pl?collection=journals&journal=03043959&issue=v104i0003&article=701_sonsneertim&form=pdf&file=file.pdf"">Full Text - Xing, Jun-Ling; Hu, San-Jue; Jian, Zhong; Duan, Jian-Hong,""Subthreshold membrane potential oscillation mediates the excitatory effect of norepinephrine in chronically compressed dorsal root ganglion neurons in the rat""Pain2003pp. 177-183
sciserv.pl?collection=journals&journal=03043959&issue=v105i1-2&article=177_smpomtrgnitr"">Bibliographic Pagesciserv.pl?collection=journals&journal=03043959&issue=v105i1-2&article=177_smpomtrgnitr&form=pdf&file=file.pdf"">Full Text - Koltzenburg, Martin,""The changing sensitivity in the life of the nociceptor""Pain1999pp. S93-S102
sciserv.pl?collection=journals&journal=03043959&issue=v82inone_s1&article=s93_tcsitlotn"">Bibliographic Pagesciserv.pl?collection=journals&journal=03043959&issue=v82inone_s1&article=s93_tcsitlotn&form=pdf&file=file.pdf"">Full Text - Honma, Yasuyuki; Yamakage, Michiaki; Ninomiya, Takafumi,""Effects of adrenergic stimulus on the activities of Ca<sup>2+sup> and K<sup>+sup> channels of dorsal root ganglion neurons in a neuropathic pain model<sup>1sup>""Brain Research1999pp. 195-206
sciserv.pl?collection=journals&journal=00068993&issue=v832i1-2&article=195_eoasotnianpm"">Bibliographic Pagesciserv.pl?collection=journals&journal=00068993&issue=v832i1-2&article=195_eoasotnianpm&form=pdf&file=file.pdf"">Full Text |
| size=""1""/>size=""-1"" color=""black""> Footnotes: Published on the World Wide Web on 26 April 1999.
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