Effects of ambient air pollution on respiratory tract complaints and airway inflammation in primary school children

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• 作者：Hicran Altu臒^a ; ^{hcinar@anadolu.edu.tr" class="auth_mail} ; Eftade O. Gaga^a ; ^{egaga@anadolu.edu.tr" class="auth_mail} ; Tuncay Dö ; 臒ero臒lu^a ; ^{tdogeroglu@anadolu.edu.tr" class="auth_mail} ; Bert Brunekreef^b ; ^{b.brunekreef@uu.nl" class="auth_mail} ; Gerard Hoek^b ; ^{G.Hoek@uu.nl" class="auth_mail} ; Wim Van Doorn^c ; ^{wim.vandoorn@royalhaskoning.com" class="auth_mail}
• 关键词：Ambient ozone ; Fractional exhaled nitric oxide ; Spirometry ; Having cold ; Runny nose ; Complaints of throat
• 刊名：Science of the Total Environment
• 出版年：1 May, 2014
• 年：2014
• 卷：479-480
• 期：Complete
• 页码：201-209
• 全文大小：598 K

文摘

Respiratory health effects of ambient air pollution were studied in 605 school children 9 to 13 years in Eski艧ehir, Turkey. Each child performed a fractional exhaled nitric oxide (FE_NO) measurement and a lung function test (LFT). Self-reported respiratory tract complaints (having cold, complaints of throat, runny nose and shortness of breath/wheezing) in the last 7 days and on the day of testing were also recorded. As acute health outcomes were investigated, weekly average ambient concentrations of ozone (O₃), nitrogen dioxide (NO₂) and sulfur dioxide (SO₂) were determined by passive sampling in the school playgrounds simultaneously with the health survey. Effects of air pollution on respiratory tract complaints and exhaled NO/lung function were estimated by multivariate logistic regression and multivariate linear mixed effects models, respectively.

Upper respiratory tract complaints were significantly (p < 0.05) associated with weekly average O₃ concentrations during the health survey (adjusted odds ratios (OR) of 1.21 and 1.28 for a 10 渭g m^鈭?#xA0;3 increment for having cold and a runny nose on day of testing, respectively). FE_NO levels were significantly (p < 0.05) increased in children with various upper respiratory tract complaints (ratio in FE_NO varied between 1.16 and 1.40). No significant change in FE_NO levels was detected in association with any of the measured pollutants (p 鈮?#xA0;0.05). Lung function was not associated with upper respiratory tract complaints and FE_NO levels. Peak Expiratory Flow (PEF) levels were negatively associated with weekly average O₃ levels for children without upper respiratory tract complaints. In summary, elevated levels of air pollutants increased respiratory tract complaints in children.