Synthesis of a hemifluorinated amphiphile designed for self-assembly and two-dimensional crystallization of membrane protein
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- 作者：Julien Dauvergne ; Ange Polidori ; Catherine Vé ; nien-Bryan ; Bernard Pucci
- 关键词：Hemifluorinated surfactants ; Langmuir film ; Membrane proteins ; Nickel complexation ; 2D proteins crystallization
- 刊名：Tetrahedron Letters
- 出版年：2008
- 出版时间：31 March 2008
- 年：2008
- 卷：49
- 期：14
- 页码：2247-2250
- 全文大小：130 K
文摘
The work reported herein deals with the synthesis and the preliminary physical–chemical analysis of new hemifluorinated surfactant made up of one fluorinated chain linked to a tricarboxylic acid polar head which is able to complex a Ni atom and should favor the two-dimensional crystallization of membrane proteins. Such a compound forms a Langmuir film which is a fluid at 20 °C and not perturbed by the presence of hydrocarbon detergent in aqueous solution.