A cholesterol-lowering VLP vaccine that targets PCSK9
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- 作者：Erin Crosseya ; 1 ; Marcelo J.A. Amarb ; 1 ; Maureen Sampsonb ; Julianne Peabodya ; John T. Schillerc ; Bryce Chackeriana ; bchackerian@salud.unm.edu" class="auth_mail" title="E-mail the corresponding author ; Alan T. Remaleyb ; aremaley1@nhlbi.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：PCSK9 ; Vaccine ; Virus-like particles ; LDL Cholesterol
- 刊名：Vaccine
- 出版年：2015
- 出版时间：26 October 2015
- 年：2015
- 卷：33
- 期：43
- 页码：5747-5755
- 全文大小：2178 K
文摘
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PCSK9 is a molecule that controls the metabolism of low-density lipoprotein cholesterol (LDL-C).
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We have generated virus-like particles based vaccines that induce high-titer antibodies against PCSK9.
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Vaccination of mice with PCSK9-VLPs resulted in reduced lipid levels.
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Macaques vaccinated with PCSK9-VLPs and coadministered statins had significant reduction in LDL-C levels.
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Vaccination against PCSK9 may be an alternative to monoclonal antibody-based therapies.