Expression and localization of the Na-K-2Cl cotransporter in the rat cochlea

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• 作者：Goto ; Satoru ; Oshima ; Takeshi ; Ikeda ; Katsuhisa ; Ueda ; Narihisa ; Takasaka ; Tomonori
• 关键词：Stria vascularis ; Marginal cell ; Fibrocyte ; Spiral ligament ; Bumetanide-sensitive Na-K-2Cl cotransporter
• 刊名：Brain Research
• 出版年：1997
• 出版时间：August 15, 1997
• 年：1997
• 卷：765
• 期：2
• 页码：324-326
• 全文大小：289 K

文摘

We identified the localization of the basolateral bumetanide-sensitive Na-K-2Cl cotransporter (BSC2) in the cochlea using an in situ hybridization method. In the rat cochlea, the BSC2 mRNA was mainly expressed in the strial marginal cells. Although the fibrocytes localized at the spiral prominence showed a weak expression of BSC2 mRNA, no expression was observed in the organ of Corti or spiral ganglion cells. The present findings are well consistent with a proposed cell model of ion transport in the marginal cell.