Long-chain saturated and monounsaturated fatty acids associate with development of premature infants up to 18 months of age

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• 作者：Birgitta Strandvik^a ; ^{birgitta.strandvik@ki.se" class="auth_mail" title="E-mail the corresponding author} ; Eleni Ntoumani^b ; Cristina Lundqvist-Persson^c ; ^d ; Karl-Gö ; ran Sabel^b
• 关键词：AA ; arachidonic acid ; AGA ; appropriate for gestational age ; BNBAS ; Brazelton Neonatal Behavioral Assessment Scale ; BSID-II ; Bayley Scales of Infant Development II ; DHA ; docosahexaenoic acid ; GC ; gas chromatography ; HC ; head circumference ; LCPUFA ; long-chain polyunsaturated fatty acids ; LiA ; lignoceric acid ; MDI ; mental developmental index ; NA ; nervonic acid ; OA ; oleic acid ; PA ; palmitic acid ; PI ; palmitoleic acid ; PDI ; psychomotor developmental index ; RBC ; red blood cells ; SA ; stearic acid ; SCD
• 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：107
• 期：Complete
• 页码：43-49
• 全文大小：571 K

文摘

Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and oleic acids correlated to growth and early development up to 18 months corrected age. Small for gestational age infants had lower concentrations than infants appropriate for gestational age. Only oleic acid was negatively correlated to long-chain polyunsaturated fatty acids. Oleic and lignoceric acids correlated to social interaction at one month, and nervonic acid to mental, psychomotor and behavioral development at 6, 10 and 18 months, also when adjusted for several confounders. Negative association between oleic acid and long-chain polyunsaturated fatty acids suggests inhibition of delta-9 desaturase, and nervonic acid´s divergent correlation to lignoceric and oleic acids suggests different metabolism in neonatal period. Our results may have implications for the supplementation of premature infants.