Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study
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- 作者：Karin Engströ ; ma ; b ; Tanzy M. Lovec ; Gene E. Watsonc ; Grazyna Zarebac ; Alison Yeatesd ; Karin Wahlberga ; Ayman Alhamdowb ; Sally W. Thurstonc ; Maria Mulhernd ; Emeir M. McSorleyd ; J.J. Straind ; Philip W. Davidsonc ; Conrad F. Shamlayee ; G.J. Myersc ; Matthew D. Randc ; Edwin van Wijngaardenc ; Karin Broberga ; b ; karin.broberg@ki.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABC ; ATP-binding cassette ; ABCB1 ; ATP-Binding Cassette Sub-Family B (MDR/TAP) Member 1 ; ABCC1 ; ATP-Binding Cassette Sub-Family C (CFTR/MRP) Member 1 ; ABCC2 ; ATP-Binding Cassette Sub-Family C (CFTR/MRP) Member 2 ; BSID-II ; Bayley scales of infant development II ; MDI ; Mental Development Index ; MDR1 ; multidrug resistance protein 1 ; MeHg ; methylmercury ; MRP1 ; Multidrug resistance-associated protein 1 ; MRP2 ; Multidrug resistance-associated protein 2 ; NC2 ; Nutrition Cohort 2 ; PDI ; Psychomotor Developme
- 刊名：Environment International
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：224-229
- 全文大小：243 K
文摘
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SNPs in three ABC transporter genes were associated with hair mercury in mothers.
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Maternal ABCC1 SNP rs11075290 was associated with child neurodevelopment.
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Genetics of ABC may determine prenatal methylmercury concentrations.