Long-chain acyl-CoA synthetase 2 knockdown leads to decreased fatty acid oxidation in fat body and reduced reproductive capacity in the insect Rhodnius prolixus
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- 作者：Michele Alves-Bezerraa ; b ; Eric L. Klettb ; c ; Iron F. De Paulaa ; Isabela B. Ramosa ; Rosalind A. Colemanb ; Katia C. Gondima ; katia@bioqmed.ufrj.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACS ; acyl-CoA synthetase ; ACSS ; short-chain ACS ; ACSM ; medium-chain ACS ; ACSBG ; bubblegum ACS ; ACSL ; long-chain ACS ; ACSVL ; very long-chain ACS ; DAG ; diacylglycerol ; FATP ; fatty acid transport protein ; PL ; phospholipid ; TAG ; triacylglycerol
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1861
- 期：7
- 页码：650-662
- 全文大小：2481 K
文摘
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Twenty acyl-CoA synthetase genes were identified.
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ACSL transcripts showed tissue-specific regulation and were dependent on nutritional status.
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ACSL isoforms were expressed and their enzymatic properties were characterized.
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ACSL2 was required for fatty acid oxidation and insect reproduction.